1. DRUG ACTION

Fludrocortisone has very high mineralocorticoid activity and insignificant glucocorticoid activity.

2. INDICATIONS AND DOSE

2.1 Neuropathic Postural Hypotension

• Adult: 100–400 micrograms daily orally.

2.2 Mineralocorticoid Replacement in Adrenocortical Insufficiency

• Adult: 50–300 micrograms once daily orally.

2.3 Adrenocortical Insufficiency Resulting from Septic Shock (in combination with hydrocortisone)

• Adult: 50 micrograms daily orally.

2.4 UNLICENSED USE

• Not licensed for use in neuropathic postural hypotension.

3. SIDE-EFFECTS

• Conjunctivitis
• Idiopathic intracranial hypertension
• Muscle weakness
• Thrombophlebitis

4. HEPATIC IMPAIRMENT

Monitor patient closely in hepatic impairment.

5. MEDICINAL FORMS

5.1 Tablet

5.1.1 Fludrocortisone acetate (Non-proprietary)

• Fludrocortisone acetate 100 microgram
  • Fludrocortisone 100 microgram tablets | 30 tablets
  • Fludrocortisone 100 microgram tablets | 100 tablets